Sunday, April 7, 2013

The neglected tropical diseases that affect over 1 billion people


This video presents seven of the Neglected Tropical Diseases that plague billions.  These diseases can be eradicated if appropriate treatment is made available.  

The neglected tropical diseases that affect over 1 billion people

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One person can make a difference.  In fact, it's not only possible for one person to make a difference, it's essential that one person makes a difference.  And believe it or not, that person is you.
- Bob Riley


Saturday, April 6, 2013

NTD's in the News this week (31 March thru 6 April 2013)


Sun.Star - ‎Apr 5, 2013‎
THE Department of Health (DOH) has recorded over 23,000 cases of dengue in the country in the first three months of the year.

pharmabiz.com - ‎6 hours ago‎
The grant provides funding of $2.2 million over a period of three years to develop a recombinant tetravalent dengue vaccine using VaxInnate's proprietary technology.

The Hindu - ‎5 hours ago‎
The dengue threat is back as health officials have admitted fever outbreak in several villages in Madurai district. As it happened last year, it is the Melur block that is kept under scanner as a large number of fever cases are being reported from ...

Solomon Star - ‎Apr 4, 2013‎
“We have more than four hundred dengue fever confirmed cases already reported and another thousand plus suspected cases,” World Health Organization's (WHO) Health Promotion and Communications Officer, Saula Volavola said.

Pakistan Observer- ‎15 hours ago‎
Administrator Saira Umar briefed Special Secretary Local Government regarding working of different departments regarding anti dengue campaign in Data Ganj Baksh Town Lahore. She told that teams are visiting Graveyards, Junkyards, Pounds and ...

ABC Online - ‎Apr 3, 2013‎
Guinea worm disease on the way out. The Guinea worm's days of using the human body as an incubator for its one-metre uterus are numbered.

The Hindu - Apr 3, 2013

In a new finding, a mutation in TAP1 gene has been associated with susceptibility to leprosy in Indians. TAP1 gene is one of the several genes that regulate the immune response and its variations were earlier implicated in tuberculosis and auto-immune ...

Philippine Star - ‎Apr 2, 2013‎
COTABATO CITY, Philippines - Health workers started on Tuesday massive fumigation operations in several villages in Kidapawan City following a rise in cases of dengue fever in recent weeks. The first area the city health office fumigated with anti ...

PakistanToday.com.pk - ‎18 hours ago‎
Punjab Excise and Taxation Department Secretary Capt (r) Zahid Saeed, while presiding over Dengue Control Committee Nishter Town, directed the Nishter Town Administration to take action against owners of old tyre shops who were not following the ...

Times of India - ‎Apr 3, 2013‎
"As dengue-causing mosquitoes breed in stagnant water, we are spraying larvicide in the drains. About 100 spraying machines and 108 people have been engaged for this purpose.

NPR (blog) - ‎Mar 13, 2013‎
Thanks to efforts from Key West health officials to combat mosquitoes, dengue transmission in the area has slowed dramatically, says the CDC's Jorge Munoz-Jordan, who led the study.

The News International - ‎Apr 1, 2013‎
He said that a vigorous public awareness drive should also be initiated regarding the importance of sanitation and preventive measures against dengue. He directed that all departments concerned should take effective measures in a well-coordinated ...

The Express Tribune - ‎Apr 2, 2013‎
In the last month, the Environment Protection Department (EPD) issued notices to 1,119 and lodged FIRs against 27 tyre shops and warehouses, scrap yards and construction sites for not following dengue-prevention guidelines. A total of 4,951 places were ...

Genetic Engineering News - ‎Apr 4, 2013‎
The grant will fund development of a recombinant tetravalent dengue vaccine using VaxInnate's technology, which involves genetically fusing vaccine antigens to the bacterial protein flagellin, with the goal of dramatically improving the potency ...

Manila Bulletin
 - ‎Apr 4, 2013‎
DENGUE FUMIGATION (April 4, 2013) - The local health office in Zamboanga City has started their dengue fumigation activities and have targeted suspected areas where mosquitoes with the deadly disease are hiding and hatching their eggs.

The News International - ‎Apr 3, 2013‎
The district allied departments have done nothing significant so far to eliminate possible breeding sites for mosquitoes to avoid a possible outbreak ofdengue fever in the region, while the recent rain has further weakened the surveillance system ...

Manila Bulletin - ‎Apr 3, 2013‎
KORONADAL CITY, South Cotabato - The Department of Health (DOH) in Soccsksargen (Region 12) recorded a total of 1,528 dengue cases in the first three months or 156 percent more compared to cases recorded during the same period last year. DoH-12 ...

GlobalPost - ‎Apr 4, 2013‎
"Of 696 patients with dengue fever during the first three months of this year, seven have died of the mosquito-borne viral infection," Mada G. Soebowo, the head of the Semarang health office`s disease control and prevention section, said here on Thursday.

The News InternationaL - ‎Apr 3, 2013‎
Salima Hashmi said that due to change of weather the atmosphere is conducive for dengue mosquito breeding, therefore, the Health Department as well as other concerned departments should pay more attention towards this issue.


JOURNAL ARTICLES
Keenan M, Alexander PW, Diao H, Best WM, Khong A, Kerfoot M, Thompson RC, White KL, Shackleford DM, Ryan E, Gregg AD, Charman SA, von Geldern TW, Scandale I, Chatelain E.
Bioorg Med Chem. 2013 Apr 1;21(7):1756-63. doi: 10.1016/j.bmc.2013.01.050. Epub 2013 Jan 31.
PMID: 23462713 [PubMed - indexed for MEDLINE]

Martins-Teixeira MB, Campo VL, Biondo M, Sesti-Costa R, Carneiro ZA, Silva JS, Carvalho I.
Bioorg Med Chem. 2013 Apr 1;21(7):1978-87. doi: 10.1016/j.bmc.2013.01.027. Epub 2013 Feb 8.

PMID: 23415086 [PubMed - indexed for MEDLINE]

Chai JY.
Infect Chemother. 2013 Mar;45(1):32-43. doi: 10.3947/ic.2013.45.1.32. Epub 2013 Mar 29. Review.
PMID: 24265948 [PubMed] Free PMC Article

Lugo-Caballero C, Ballesteros-Rodea G, Martínez-Calvillo S, Manning-Cela R.
Biomed Res Int. 2013;2013:493525. doi: 10.1155/2013/493525. Epub 2013 Mar 17.
PMID: 23586042 [PubMed - indexed for MEDLINE] Free PMC Article

Gupta S, Garg NJ.
PLoS One. 2013;8(3):e59434. doi: 10.1371/journal.pone.0059434. Epub 2013 Mar 26.
PMID: 23555672 [PubMed - indexed for MEDLINE] Free PMC Article

Araújo AB, Berne ME.
Braz J Infect Dis. 2013 Mar-Apr;17(2):174-8. doi: 10.1016/j.bjid.2012.10.013. Epub 2013 Feb 28.
PMID: 23453943 [PubMed - indexed for MEDLINE]

Parada-López J, Hernández-Betancourt SF, Ruiz-Piña HA, Escobedo-Ortegón FJ, Medina-Peralta S, Panti-May JA.
Ecohealth. 2013 Mar;10(1):31-5. doi: 10.1007/s10393-013-0819-5. Epub 2013 Feb 13. No abstract available.
PMID: 23404037 [PubMed - indexed for MEDLINE]

Enriquez GF, Cardinal MV, Orozco MM, Lanati L, Schijman AG, Gürtler RE.
Parasitology. 2013 Mar;140(3):303-8. doi: 10.1017/S003118201200159X. Epub 2012 Oct 12.
PMID: 23058180 [PubMed - indexed for MEDLINE] Free PMC Article

Pinto FS, de Andrade GM, Januario JN, Maia MC, Gontijo ED.
Rev Soc Bras Med Trop. 2013 Mar-Apr;46(2):196-9.
PMID: 23740060 [PubMed - indexed for MEDLINE] Free Article

Chai JY.
Infect Chemother. 2013 Mar;45(1):32-43. doi: 10.3947/ic.2013.45.1.32. Epub 2013 Mar 29. Review.
PMID: 24265948 [PubMed] Free PMC Article

Leslie J, Garba A, Boubacar K, Yayé Y, Sebongou H, Barkire A, Fleming FM, Mounkaila I, Adamou S, Jackou ML.
Int Health. 2013 Mar;5(1):78-84. doi: 10.1093/inthealth/ihs010. Epub 2013 Jan 3.
PMID: 24029850 [PubMed - in process]

Mahmud MA, Spigt M, Mulugeta Bezabih A, López Pavon I, Dinant GJ, Blanco Velasco R.
Pathog Glob Health. 2013 Mar;107(2):58-65. doi: 10.1179/2047773213Y.0000000074.
PMID: 23683331 [PubMed - indexed for MEDLINE]

Galinier R, Portela J, Moné Y, Allienne JF, Henri H, Delbecq S, Mitta G, Gourbal B, Duval D.
PLoS Pathog. 2013 Mar;9(3):e1003216. doi: 10.1371/journal.ppat.1003216. Epub 2013 Mar 21.
PMID: 23555242 [PubMed - indexed for MEDLINE] Free PMC Article

Raso P, Sander EM, Raso LA, Andrade Filho Jde S.
Rev Soc Bras Med Trop. 2013 Mar-Apr;46(2):252-4. doi: 10.1590/0037-8682-1681-2013.
PMID: 23740071 [PubMed - indexed for MEDLINE] Free Article

Ferragine CE, Walls CD, Davies SJ.
PLoS Negl Trop Dis. 2013;7(3):e2136. doi: 10.1371/journal.pntd.0002136. Epub 2013 Mar 21.
PMID: 23556020 [PubMed - indexed for MEDLINE] Free PMC Article

Coulibaly JT, N'Gbesso YK, Knopp S, N'Guessan NA, Silué KD, van Dam GJ, N'Goran EK, Utzinger J.
PLoS Negl Trop Dis. 2013;7(3):e2109. doi: 10.1371/journal.pntd.0002109. Epub 2013 Mar 21.
PMID: 23556011 [PubMed - indexed for MEDLINE] Free PMC Article

Carlton EJ, Hubbard A, Wang S, Spear RC.
PLoS Negl Trop Dis. 2013;7(3):e2098. doi: 10.1371/journal.pntd.0002098. Epub 2013 Mar 7.
PMID: 23505589 [PubMed - indexed for MEDLINE] Free PMC Article

Pan W, Zhou HJ, Shen YJ, Wang Y, Xu YX, Hu Y, Jiang YY, Yuan ZY, Ugwu CE, Cao JP.
PLoS One. 2013;8(3):e59746. doi: 10.1371/journal.pone.0059746. Epub 2013 Mar 26.
PMID: 23555767 [PubMed - indexed for MEDLINE] Free PMC Article

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"Give a man health and a course to steer, and he'll never stop to trouble about whether he's happy or not."
- George Bernard Shaw





Wednesday, April 3, 2013

Neglected Tropical Diseases in the News

Below are some articles that have appeared in the news this past month regarding NTDs.

March 6, 2013
Tanzania: Health Experts Salute Tropical Diseases Control Programme

March 10, 2013
Tanzania: Interventions to Tackle Neglected Tropical Diseases Take Shape

March 14, 2013
Cancer Drugs May Cure Tapeworm Diseases
Using Cancer Treatment For Diseases Caused By Tapeworms

March 21, 2013
Health: Consultative meeting on Neglected Tropical Diseases NTDs

March 25, 2013
Tokyo Institute of Technology and Astellas Use Supercomputer to Fight Tropical Diseases

March 27, 2013
Inaugural infectious disease conference brings global health leaders to St. Louis
Health: WHO nudges countries on neglected tropical diseases

March 28, 2013
Twin Pillars of Poverty in Black America: NTDs and Incarceration

April 1, 2012
Texas Tech Biologist Earns $1.6 Million NIH Grant to Find Weakness in Parasitic Leishmania

Li XX, Zhou XN.
Parasit Vectors. 2013 Mar 22;6:79. doi: 10.1186/1756-3305-6-79. Review.
PMID: 23522098 [PubMed - indexed for MEDLINE] Free PMC Article

Abera B, Alem G, Yimer M, Herrador Z.
J Infect Dev Ctries. 2013 Mar 14;7(3):253-60. doi: 10.3855/jidc.2539.
PMID: 23493004 [PubMed - indexed for MEDLINE] Free Article



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"I've learned that you shouldn't go through life with a catcher's mitt on both hands; you need to be able to throw something back."
- Maya Angelou


Tuesday, April 2, 2013

In the News today: Tropical Diseases Infect 1 in 6 People Worldwide

Article from today's ABC News.

Tropical Diseases Infect 1 in 6 People Worldwide

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"Being ignorant is not so much a shame, as being unwilling to learn."
- Benjamin Franklin


Monday, April 1, 2013

Taking a Closer Look at these Diseases

Over the next several weeks I will be discussing these Neglected Tropical Diseases individually.  In doing so, my hope is that one will then have a better understanding as to what each of these diseases are and what a devastating impact they can have people and the community.  

To recap, these diseases are as follows:
  • Buruli Ulcer (Mycobacterium ulcerans infection)
  • Chagas disease
  • Dengue/Severe dengue
  • Dracunculiasis (guinea-worm disease)
  • Echinococcosis
  • Foodborne trematodiases (Clonorchiasis, Fascioliasis, Opisthorchiasis, Paragonimiasis)
  • Human African trypanosomiasis (Sleeping sickness)
  • Leishmaniasis
  • Leprosy (Hansen's Disease)
  • Lymphatic filariasis
  • Onchocerciasis (River blindness)
  • Rabies
  • Schistosomiasis
  • Soil transmitted helminthiases - which include roundworms (Ascaris lumbricoides), whipworms   (Trichuris trichiura) and the hookworms (Necator americanus and Ancylostoma duodenale).
  • Taeniasis/Cysticercosis
  • Trachoma
  • Yaws (Endemic treponematoses)
I will also plan to focus on three other  'neglected' conditions identified by the WHO, which include:
  • Podoconiosis
  • Snakebite
  • Strongyloidiasis
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"Knowledge has to be improved, challenged, and increased constantly, or it vanishes."
- Peter Drucker